mellan olika species, vilket kan förklara de ibland inkongruenta resultaten [5]. a benefit of taurine as a component of cardioplegic solutions (Oriyanhan et al.,

The cardioplegia type variable entered into the model of 30-day mortality, but without statistical significance. This observation is similar to other studies where type of used cardioplegia did not impact in-hospital mortality [13, 15]. Cardioplegia type was not a predictor in mechanical ventilation time and intensive care unit stay time models.

Mishra and R. Jadhav and C. Mohapatra and J. Khandekar and Chaitanya Raut and Ganesh Kumar K. Ammannaya and H. Seth and J. Singh and V. Shah}, journal={Kardiochirurgia i cardioplegic solution containing histidine, tryptophan and ketoglutarate. Aim: we compared the myocardial protective effects of 3 types of cardioplegia solution: The histidine–tryptophan– ketoglutarate (HTK) solution, blood and St.Thomas cardioplegia in pediatric cardiac surgery. inal Melrose solution. The quantity of blood/cardioplegia mixture is recorded, and Ca ++ is lowered to 0.5 to 0.6 µmol/L with a 4:1 mixture and more severely, to 0.2 to 0.3 µmol/L, in solutions for energy-depleted hearts or those with acute myocardial infarction. Similar testing with crystalloid Bretschneider solution or St The cardioplegia type variable entered into the model of 30-day mortality, but without statistical significance. This observation is similar to other studies where type of used cardioplegia did not impact in-hospital mortality [13, 15]. Cardioplegia type was not a predictor in mechanical ventilation time and intensive care unit stay time models.

Cardioplegia solution types

- the 'extracellular-type' and the an electrolyte solution at 4° C with mannitol, 25 gmll., and potassium, 26 mEqlL, and group MgKCP Aside from the type of cardioplegic solution utilized,. HTK is an intracellular type of cardioplegic solution. It lowers concentrations of sodium and calcium thereby inducing cardiac arrest by deprivation of extracellular. Introduction:Myocardial protection is performed using diverse cardioplegic (CP) solutions with various combinations of chemical and blood constituents.

Kotani and colleagues collected data from 56 members of the Congenital Heart Surgeons’ Society in North America and found marked variation in the type of cardioplegia used. 8 Whilst blood-based cardioplegia was preferred by 86% of respondents, with del Nido solution (38%) the most popular, the next most frequent was ‘other’ (34%), custom-mixed solutions unique to an individual centre.

Klamerus KJ, Munger MA. Eleven institutions that participated in the Coronary Artery Surgery Study (CASS) were surveyed to obtain information about the types of cardioplegic solutions used at these institutions. A short- Se hela listan på drugs.com These axioms form the foundation for most cardioplegic solutions today. However warm cardioplegia was successfully introduced in 1995 by Calafiore and colleagues.

Jan 8, 2020 Generally, different cardioplegia solutions are available for inducing 55 ± 15%, CCP 63 ± 17% [p = 0.99]) in both types of cardioplegia (Fig.

Cardioplegia Solution A requires the aseptic addition of 10mL Sodium Bicarbonate 8.4% w/v Compared with multidose cardioplegia, there were advantages in adopting single-dose cardioplegia only in the form of DN solution. Indeed, DN was able to reduce operative times, reperfusion fibrillation, and peak of cardiac enzymes. These effects were not replicated by HTK, which on the contrary increased CPB time and reperfusion fibrillation. Cold cardioplegia is the prevalent method of myocardial protection in paediatric patients; however, warm cardioplegia is used as part of usual care throughout the UK in adults. We aim to provide evidence to support the use of warm versus cold blood cardioplegia on clinical and biochemical outcomes during and after paediatric congenital heart surgery.

Some cardioplegias, such as del Nido or Histidine-Tryptophan-Ketoglutamate solutions, offer an advantage over blood and other crystalloid cardioplegia as they only require one administration during short cardiac surgeries, compared to multiple hits required by blood and other crystalloid. Alternatives to cardioplegia The patients were randomized in three groups according to the characteristics of cardioplegia and reperfusion: cold blood cardioplegia with unmodified blood reperfusion (control group, 11 patients), crystalloid cardioplegia and reperfusion (Hôpital Lariboisière protocol, 11 patients) and crystalloid cardioplegia with allopurinol enriched blood reperfusion (Hôpital Broussais protocol, 11 patients). Custodiol ® solution, also called histidine-tryptophan-ketoglutarate (HTK) or Bretschneider’s solution, is a particular kind of long-acting intracellular crystalloid cardioplegia (CCP) that differs from other extracellular cardioplegic solutions because of its low sodium and potassium content that induce the diastolic cardiac arrest through an hyperpolarization of the myocyte plasma membrane. Cardioplegia Solution ‘A’ is an isotonic crystalloid solution based on extracellular fluid ionic concentrations. Approximate osmolality is 275 mOsm/kg and approximate pH is 3.7. Cardioplegia Solution ‘A’ requires the aseptic addition of 10 mL Sodium Bicarbonate 8.4% w/v Injection B.P. prior to use to adjust the pH to 7.4-7.8.
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Basic characteristics of cardioplegia solutions include temperature, osmolarity, and pH. Crystalloid solution has traditionally been used as a vehicle for cardioplegia solution; however, laboratory and clinical studies have demonstrated favorable effects of blood-based cardioplegia solution.

Custodiol ® solution, also called histidine-tryptophan-ketoglutarate (HTK) or Bretschneider’s solution, is a particular kind of long-acting intracellular crystalloid cardioplegia (CCP) that differs from other extracellular cardioplegic solutions because of its low sodium and potassium content that induce the diastolic cardiac arrest through an hyperpolarization of the myocyte plasma membrane. Cardioplegia Solution ‘A’ is an isotonic crystalloid solution based on extracellular fluid ionic concentrations. Approximate osmolality is 275 mOsm/kg and approximate pH is 3.7.